Translational Research Programs
Our work is built on robust clinical cohorts that provide the molecular foundation for the next generation of pediatric critical care. Through the Precision Sepsis Care Initiative, we collaborate across disciplines to translate discovery-based immunology into real-time bedside solutions for critically-ill children.
Clinical Cohorts
SHIFT
The SHIFT Cohort: A 148-patient biorepository of pediatric patients with multiple organ dysfunction syndrome (MODS). SHIFT is our primary engine for endotype discovery and functional validation, and we have longitudinal multi-omics data on all patients from onset through recovery.
Funding: K12HD047349 (PCCTSDP) | Thrasher Early Career Award | Institutional Funds
TIDES
The TIDES Cohort: An actively enrolling cohort focused on identifying the molecular drivers of T cell dysregulation in sepsis. As the primary scientific engine for the PSCI, TIDES aims to validate real-time rapid endotyping assays that allow for the translation of precision therapeutics to the bedside.
Funding: NIGMS K23GM159013 | Institutional Funds
Active Translational Studies
PSCI
Precision Sepsis Care Initiative: A collaborative institutional program transforming sepsis care by bridging discovery-based multi-omics with real-time endotyping. PSCI utilizes the Ella platform to translate endotype-specific molecular signatures into actionable bedside diagnostics.
GENESIS
Genomic Susceptibility in Sepsis: This study interrogates the genetic determinants of immune dysregulation in sepsis using Whole Genome Sequencing (WGS), with the aim of developing a clinical genomics assay for rapid diagnosis of Inborn Errors of Immunity (IEI).
IMPRINT
Immuno-Coagulopathic Profiling in TAMOF: Led by Steven D. Ham, MD, this NICHD-funded study investigates the role of neutrophil-complement dysregulation in the immunopathology of TAMOF using computational approaches and ex vivo microfluidics assays.
EFU-Bronchiolitis
Collaborative multi-center research interrogating immune dysregulation and biological endotypes in severe pediatric bronchiolitis.
PSBS
Collaborative multi-center research integrating spectral flow cytometry and proteomics to study pediatric sepsis endotypes at ED presentation.
TROPICS
Collaborative multi-center research evaluating outcomes and biological trajectories in pediatric patients with sepsis who require blood transfusions.
