Scientific Impact & Discovery
The Lindell Lab is dedicated to disseminating high-impact translational research. Our work focuses on understanding the molecular mechanisms of sepsis to deliver breakthroughs for the most critically ill children.
2026
Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype.
Lindell RB, Sayed SU, Campos Duran JS, Sheetz SA, Babu A, Knight MS, Mauracher AA, Hay CA, Conrey PE, Fitzgerald JC, Yehya N, Famularo ST III, Arroyo T, Tustin R III, Fazelinia H, Behrens EM, Teachey DT, Forbes Satter LR, Freeman AF, Bergerson JRE, Holland SM, Leiding JW, Weiss SL, Hall MW, Taylor DM, Feng R, Wherry EJ, Meyer NJ, Henrickson SE. J Clin Invest. 2026;136(13).
Pediatric Sepsis: Evolving Subphenotypes, Overlap Syndromes, and the Path to Precision Therapies.
Ham SD, Fitzgerald JC, Lindell RB. Clin Chest Med. 2026;47(1):57-66.
Arterial Catheter-Associated Proximal Ischemic Injury in Critically Ill Children: Evidence of Endothelial Dysfunction and Immune Dysregulation.
Demopoulos A, Weber MD, Liu H, Traynor D, Sayed S, Famularo ST, 3rd, Arroyo T, Conlon T, Henrickson SE, Lindell RB. Pediatr Crit Care Med. 2026;27(6):732-739.
2025
New sepsis-associated morbidity and mortality in pediatric oncology patients.
Alcamo AM, Lindell RB, Sheetz SA, Ham SD, Strayer A, Weiss SL, Nishisaki A, Pinto NP, Topjian AA, Fitzgerald JC. Front Oncol. 2025;15:1638516.
A Method for Comparing Proteins Measured in Serum and Plasma by Olink Proximity Extension Assay.
Shraim R, Diorio C, Canna SW, Macdonald-Dunlop E, Bassiri H, Martinez Z, Malarstig A, Abbaspour A, Teachey DT, Lindell RB, Behrens EM. Mol Cell Proteomics. 2025;24(7):101000.
2024
Charting a course for precision therapy trials in sepsis.
Lindell RB, Meyer NJ. Lancet Respir Med. 2024;12(4):265-7.
Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF Syndrome.
Duran JSC, Sayed S, Dalalo MC, Mauracher AA, Knight MS, Conrey PE, Schultz AB, Hay CA, Lindell RB, Howard CA, Abrams ED, Schmitt EG, Thelin MA, Bluestein S, Seroogy CM, Pozos TC, Thatayatikom A, Lundgren I, Gauthier A, Canna SW, Su HC, Keller MD, Delmonte OM, Satter LRF, Holland SM, Bergerson JRE, Leiding JW, Romberg N, Freeman AF, Villarino AV, Anderson MS, Cooper MA, Vogel TP, Henrickson SE. bioRxiv. 2024.
2023
Immunocompromised Children With Acute Respiratory Distress Syndrome Possess a Distinct Circulating Inflammatory Profile.
Nguyen J, Thompson JM, Balcarcel DR, Alder MN, McKeone DJ, Halstead ES, Rowan CM, Lindell RB, Yehya N. Crit Care Explor. 2023;5(1):e0844.
Interrogating the sepsis host immune response using cytomics.
Lindell RB, Meyer NJ. Crit Care. 2023;27(1):93.
2022
Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children with Sepsis.
Weiss SL, Henrickson SE, Lindell RB, Sartori LF, Zhang D, Bush J, Farooqi S, Starr J, Deutschman CS, McGowan FX, Jr., Becker L, Tuluc F, Wherry EJ, Picard M, Wallace DC. Shock. 2022;57(5):630-8.
Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associated with Features of Immunometabolic Dysregulation.
Lindell RB, Zhang D, Bush J, Wallace DC, Rabinowitz JD, Lu W, Wherry EJ, Weiss SL, Henrickson SE. Shock. 2022;57(6):191-9.
Duration of pre-intubation respiratory support is associated with increased mortality in immunocompromised children with respiratory failure.
Lindell RB, Fitzgerald JC, Rowan CW, Flori HR, Di Nardo M, Napolitano N, Traynor DM, Lenz KB, Emeriaud G, Jeyapalan A, Nishisaki A. Crit Care Med. 2022;50(7):1127-1137.
2021
Immune Stimulation With Recombinant Human Granulocyte Colony-Stimulating Factor for Coronavirus Disease 2019 (COVID-19)-Beware of Blind Spots.
Meyer NJ, Lindell RB, Wherry EJ. JAMA Intern Med. 2021;181(1):78-80.
2020
Risk of Mortality in Immunocompromised Children With Severe Sepsis and Septic Shock.
Lindell RB, Nishisaki A, Weiss SL, Traynor DM, Fitzgerald JC. Crit Care Med. 2020;48(7):1026-33.
2019
Comparison of methods for identification of pediatric severe sepsis and septic shock in the Virtual Pediatric Systems database.
Lindell RB, Nishisaki A, Weiss SL, Balamuth F, Traynor DM, Chilutti MR, Grundmeier RW, Fitzgerald JC. Crit Care Med. 2019;47(2):e129-e135.
2017
High levels of morbidity and mortality among pediatric hematopoietic cell transplant recipients with severe sepsis: insights from the SPROUT international point prevalence study.
Lindell RB, Gertz SJ, Rowan CM, McArthur J, Beske F, Plunkett A, Weiss SL, Thomas NJ, Nadkarni VM, Fitzgerald JC. Pediatr Crit Care Med. 2017;18(12):1114-1125.