Welcome to the Lindell Lab!

At the forefront of pediatric sepsis research, the Lindell Lab is dedicated to transforming pediatric sepsis care through precision immunology. Based at Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania Perelman School of Medicine, our mission is to uncover the molecular mechanisms driving immune dysregulation in critically ill children. By integrating cutting-edge technologies—from proteomics to machine learning—we aim to identify treatable sepsis subphenotypes and develop precision therapeutics that improve the lives of critically-ill children.

Celebrating our 100th patient enrollment in April 2023.

What drives our work?

The major goal of our lab is to leverage translational immunology to improve the care we provide to children with critical illness. Immunology is a rapidly developing field, and the University of Pennsylvania is a national leader in the application of translational immunology to diagnose and treat disease. At its core, the immune system is a complex network of molecular sensors which continuously surveils the human proteome. In addition to causing some forms of critical illness—including sepsis—the immune system has the power to monitor for and identify pathology throughout the body, essentially functioning as a sensory organ. As immune technologies continue to advance, we expect to find increasing roles for both immunodiagnostics and immunotherapeutics in pediatric critical care medicine.